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《医学前沿（英文）》 2018年 第12卷 第2期 页码 189-195 doi: 10.1007/s11684-017-0533-8
Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.
关键词： obstructive sleep apnea Berlin Questionnaire Chinese surgical patients adverse respiratory event
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
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《医学前沿（英文）》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词： chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
Interactions between remote ischemic conditioning and post-stroke sleep regulation
《医学前沿（英文）》 2021年 第15卷 第6期 页码 867-876 doi: 10.1007/s11684-021-0887-9
Effects of modafinil on vestibular function during 24 hour sleep deprivation
ZHAN Hao, XIE Sujiang, JIA Hongbo, WEI Sihuang, JING Baisheng
《医学前沿（英文）》 2007年 第1卷 第2期 页码 226-229 doi: 10.1007/s11684-007-0044-0
关键词： VVOR modafinil Vestibular function vestibular functional Initially
ZHU Lidong, CHEN Xiaoping
《医学前沿（英文）》 2007年 第1卷 第4期 页码 364-368 doi: 10.1007/s11684-007-0070-y
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 368-375 doi: 10.1007/s11684-014-0360-0
This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects: frequency of acute exacerbation (P≤0.040), duration of acute exacerbation (P = 0.034), symptoms (P≤0.034), 6-min walking distance (6MWD) (P≤0.039), dyspnea scale (P≤0.036); physical domain (P≤0.019), psychological domain (P≤0.033), social domain (P≤0.020), and environmental domain (P≤0.044) of the WHOQOL-BREF questionnaire; and daily living ability domain (P≤0.007), social activity domain (P≤0.018), depression symptoms domain (P≤0.025), and anxiety symptoms domain (P≤0.037) of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.
关键词： chronic obstructive pulmonary disease older adult clinical trial Bu-Fei Jian-Pi granules Bu-Fei Yi-Shen granules Yi-Qi Zi-Shen granules
标题 作者 时间 类型 操作
Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse respiratory events in post anesthesia care unit
null
期刊论文
Effects of modafinil on vestibular function during 24 hour sleep deprivation
ZHAN Hao, XIE Sujiang, JIA Hongbo, WEI Sihuang, JING Baisheng
期刊论文
Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice
ZHU Lidong, CHEN Xiaoping
期刊论文
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